There are a lot of great Aerosmith songs to choose from; while this song isn't my first choice, Dude (Looks Like a Lady) has always been a favorite, if only for Robin Williams' dance to the song in the movie, Mrs. Doubtfire. What inspired the band to write this song?
The song, which originally started out as "Cruisin' for a Lady," talks about a male with an effeminate appearance who is mistaken for a female. There is a story that the song was inspired by the glam look of the members of Mötley Crüe and their constant usage of the word "dude." Steven Tyler says in the book Walk This Way: The Autobiography of Aerosmith, "Then one day we met Mötley Crüe, and they're all going, 'Dude!' Dude this and Dude that, everything was Dude. 'Dude (Looks Like a Lady)' came out of that session."
In his recent book, The Heroin Diaries, Nikki Sixx of Mötley Crüe claims that the song was specifically inspired by Vince Neil, singer with Mötley Crüe.